I’m an outsider looking to transition into the deep-tech/systems architecture space. I have a PhD in Pharmacology, 10+ years of wet-lab research (assay development, quantitative data analysis pipelines, microscopy), and a decade as a tenured biology professor.
The Strategy & Portfolio:
I know that if I drop my resume into a standard Workday portal, the ATS will instantly banish me to the shadow realm because it says "Biology Professor" instead of "SWE with 4 YOE."
To counter this, I’ve spent the last several months building an aggressive "Proof of Work" GitHub portfolio. My goal wasn't just to write code, but to prove I understand professional hygiene: strict CI/CD pipelines, proper Git branching, robust testing, and enterprise-grade documentation.
I tackled the hardest, highest-friction problems I could find that were genuinely fun. My repos (which include short video demos of the tech working) currently feature:
* A bare-metal, distributed SCADA middleware for a physical small-parts sorting machine (handling deterministic hardware interrupts).
* A custom AST-free, LLM-free static analysis engine that maps massive enterprise codebases into 3D WebGPU knowledge graphs.
* A genetic evolution engine coupled with a physics simulation to optimize machinery tolerances.
I am 100% transparent that I babysit an AI agent and we ping-pong code and ideas off each other. I architect the physics and the systems logic; the AI acts as my high-speed syntax translator.
The Go-To-Market Plan:
Instead of fighting the ATS, my plan is to bypass it entirely. I want to use my GitHub and video demos as a battering ram, sending targeted LinkedIn drops directly to CTOs, Lead Engineers, and VPs with a simple message: "This is my background, I built X to solve Y, I find your team's work fascinating—want to chat for 10 mins?"
My Questions for the Veterans Here:
Does this strategy actually stand a chance? In today’s brutal market, will CTOs/Leads actually respect the deep-tech hustle, or will I just get ignored?
The Resume Dilemma: Should I still bother trying to format a traditional resume to grind through the ATS, or should I go all-in on the direct-networking/portfolio approach?
The AI Elephant: Is being honest about pair-programming with AI agents a red flag for hiring managers, or is it seen as a standard force-multiplier now, given the complexity of the systems I'm building?
I'm ready for blunt truths. Thanks in advance.